According to the Davis's Drug Guide for Nurses, Valerian can produce benzodiazepine-like withdrawal symptoms after long-term use.

From other sources:

"Valerian does effect the GABA system, although not as much as benzodiazepines. Valerian can potentiate (increase) the effect of benzodiazepines. Some individuals may experience a paradoxical reaction to this herb, associated with anxiety, tachycardia, and insomnia, and thus a gradual increase in dose should be recommended to first-time users."

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Last updated 21 July 2020